Actinal

Registered Trademark of Richmond Veterinaria S.A.
Prednisolone 20 mg
VETERINARY USE

Composition
Prednisolone 20 mg, Excipients q.s.f 500 mg

Information
Oral corticoid / Antiphlogistic / Antiallergic.
Allergic states in general.
Non-infectious inflammatory states and hypersensitivity.
Immunosuppression in tumour processes.
Allergic dermopathies / Non-septic arthropathies / Lymphoma.

Steroids in general interact with specific receptor proteins in the target tissues to regulate the expression of genes with response capacity to corticosteroids, which modifies the numbers and the disposition of the proteins synthesized by the different target tissues.

Steroids act on the number of lymphocytes, profoundly altering the immune reactions of the lymphocytes; these effects constitute an important facet of the anti-inflammatory and immunosuppressive activity of glucocorticoids.

The anti-inflammatory and immunosuppressive actions of glucocorticoids are intrinsically linked, perhaps because both originate largely from the inhibition of specific leukocyte functions.

With respect to the chemical structure of prednisolone in relation to other glucocorticoids, since it has a double bond in the 1.2 position of ring A, the glucocorticoid activity is increased (four times with respect to hydrocortisone).

DOSAGE
In dogs and cats 1 – 2 mg per kilogram of weight, oral, every 12 to 24 hours for 3 to 5 days.
In prolonged treatments, as maintenance, administer it every 48 hours decreasing the dose every 7 – 10 days until achieving maintenance with the minimum possible.
In dogs it is convenient to administer it in the first hours of the morning, to respect the circadian cycle.
In cats it is preferable at night.

CONTRAINDICATIONS:
Do not administer in pregnant females.
Administer with caution in corneal ulcer, glaucoma, diabetes mellitus, Cushing’s disease, renal or cardiac insufficiency.
Do not administer in animals with bacterial infections.
Muscle weakening in thin animals and growth inhibition in young animals must be taken into account.
Liver diseases may occur in the dog, which reverts when treatment is interrupted.
Precautions should be taken when routinely administered and when used in the case of inflammatory liver lesions.
Treatment at high doses for several weeks produces adrenal atrophy.
Consideration should be given to the depressing action it has when the animal is being vaccinated.

PRECAUTIONS:

A large but single dose, lacks adverse effects, as does a short treatment.
If the duration of treatment with glucocorticoid is greater than one week there is an increase in the incidence of disabling and potentially lethal effects.
Except when the drug is given in replacement or substitution treatments (glucocorticoids do not act as specific or curative), and instead provide palliation by virtue of their anti-inflammatory and immunosuppressive effects.
Finally, the sudden cessation of glucocorticoids after prolonged treatment is associated with a significant risk of adrenal insufficiency, which can be lethal.
That is why it is recommended to gradually decrease the dose, and not to cut the treatment suddenly.

Store between 15 and 30 ºC, away from direct sunlight, in a dry and hygienic place, keeping it in its original packaging.

Keep out of reach of children and pets.

Actinal. Case containing 20 blisters. Blister for 10 tablets.

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