Bovicine I

Ivermectin 1%

Registered Trademark of Richmond Veterinaria S.A.

Antiparasitic endectocide indicated for the treatment and control of internal and external parasites. Ready to use sterile injectable solution.

Composition 

• Ivermectin 1,0 g
• Excipients csp. 100.0 mL

General Description   

Its active principle (Ivermectin) is a molecule belonging to the Avermectin family, isolated from the fermentation of Streptomyces avermitilis, known for its powerful parasiticide action and broad spectrum, both against internal parasites (round worms), and external ones (scabies, lice and other mites and insects). The action of Ivermectin is located at the level of the nerve endings themselves or in the contact zone between a nerve fiber and a muscle fiber.

Ivermectin stimulates the massive release at this level of a chemical compound, Gamma Aminobutyric Acid or GABA, which acts as a neurotransmitter. The presence of large quantities of GABA at the synaptic level leads to a total blockage of the specific receptors located at the nerve endings, which produces the interruption of the parasite’s nerve impulses and consequently its death by paralysis. This original mode of action is specific to Ivermectin and distinguishes it from the other families of antiparasitic substances.

Indications for use

CATTLE:

BOVICINE I is indicated for the treatment and control of the following species of parasites:

Gastrointestinal worms (adults and larvae) Ostertagia ostertagi (including inhibited larvae), O. iyrata, Haemonchus placei, Trichostrongylus axei, T. columbiformis, Cooperia oncophora, C. punctacta, Bunostomun phlebotomun, Oesophagostomun radiatum (adults), Nematodirus helvetianus (adults), N. spathiger and Strongiloides papillosus. Lung Worms (adults and larvae) Dictyocaulus viviparus. Ura/Hypodermosis (parasitic forms) Dermatobia hominis, Hypoderma bovis, H. lineaturn.

• Paraphilosis Bovine paraphilaria.
• Eyeworm Thelazia spp.
• Lice Lignonatus vituli, Haematophinus eurysternus.
• Sarna Psoroptes comunis variedad bovis, Sarcoptes scabiei variedad bovis.
• It is also indicated to help control parasite infestations produced by:
• Lice: Damalinia bovis.
• Scabies: Produced by Chorioptes bovis.

SWINE

BOVICINE I is indicated for the treatment and control of the following species of parasites:

• Gastrointestinal worms.
• Ascaris suum (adults and larvae), Hyostrongylus rubidus (adults and larvae), Strongyloides ransomi (adults and larvae).
• Lung Worms: Metastrongylus spp.
• Lice: Haematophinus suis.
• Scabies: Sarcoptes scabiei variety suis.

Dosage

• Bovine: 200 micrograms per kg of weight – Equivalent to 1 mL every 50 kg of weight.
• Swine: 300 micrograms per kg of weight. Equivalent to 1 mL every 33 kg of weight.
• Administer by subcutaneous injection only.

Collateral Effects

At recommended doses, Bovicine I does not produce adverse effects in cattle and pigs since the main neurotransmitter at peripheral level in mammals is Acetylcholine and not GABA, which provides a high safety margin to the technician, when administering the product.

Warnings and Precautions

• Do not administer by intravenous or intramuscular route.
• Do not administer in animals in poor general condition, or in situations of intense stress.
• Do not administer in milk producing animals, nor during the 28 days prior to delivery.
• Adjust the dose to the weight of each animal to avoid overdosing.
• Do not ingest. Keep out of reach of children and domestic animals. Keep between 15 and 30 °C, away from light, in a dry and hygienic place.
• Check the integrity of the seals before use.
• Keep the indications of asepsis and antisepsis before and during application.

Withdrawal period 

Cattle: Do not send meat from treated animals for human consumption until 35 days after the last application of the product.

Swine: Do not send treated pigs for slaughter until 18 days after the last treatment.

Suggestions 

• It is suggested that the animals to be treated do not suffer from stress conditions before or after administration (prolonged confinement, mistreatment, exposure to high environmental temperatures for long periods of time, severely malnourished or feverish animals).
• Do not mix in the same syringe or container with any other substance foreign to the product.
• Always consult your veterinarian.
• Destroy after use, do not contaminate the environment.

Bovicine. Vials of 50, 100 and 500 mL of Sterile Injectable Solution. 

Sale under prescription/prescription of the veterinarian.