Trademark of Richmond Vet Pharma S.A
Bupivacaína HCL 0,50 %
Bupinex Vet. Long acting local anesthetic for use in large and small animals. Ready to use injectable sterile solution.
Every 100 mL of solution contains:
Bupivacaine Hydrochloride 0,5 g; Excipients qsf 100,00 mL
- Bupinex Vet is a modern local anesthetic belonging to the Amides group. Its action is prolonged and lasts between 4 to 8 hs after delivery.
- Bupivacaína has a potency of 2 to 4 times higher than Lidocaine, being its margin of safety even greater.
- The action of Bupivacaine begins between the 3 to 20 minutes after its application.
- Bupinex Vet is an aqueous injectable solution, that contains the equivalent to 5,0 mg of Bupivacaine Hydrochloride for each mL of injectable sterile solution.
- Bupivacaine is a new therapeutic tool of great utility in current Veterinary Medicine. It is a local anesthetic agent that allows us to work with great safety and versatility, making it the first choice for all types of minor surgical interventions of long duration and medium to low complexity.
- Its anesthetic power is optimal, also maintaining a powerful post-surgical analgesic effect.
Bupinex Vet works directly by blocking the excitatory conduction of the nerves, through the stabilization of the neuronal membrane.
The membrane remains in phase “0” of depolarization, thus blocking the transmission of the nerve impulse. Pain is the first thing that patient loses and the last thing he recovers.
Bupinex Vet ennables excellent post surgical pain control, due to its prolonged action.
Possibility of dilutions for your specific use:
Bupivacaína in 0, 50 % solution is the concentration of choice to be used in routine veterinary practice. This concentration will allow the use of the 0, 5 % agent or will in turn give it the possibility of being diluted 0, 25 % with physiological solution or bidistilled sterile water for injection. It should be borne in mind that by producing the dilution of the drug in water, we will increase the volume of the anesthetic in the tissue, the duration in time will be less, but its analgesic and anesthetic potency power will remain intact. Another form of combined dilution is the 50% mixture (equal parts) of Bupivacaine 0, 5% in equal volume of Lidocaine 2%
With this combination we will be able to obtain a shorter latency time due to the rapid action of the Lidocaine, increasing the potency and the duration over time of the anesthetic and analgesic effects of Bupivacaine itself.
Indications for use and routes of application
Bupinex Vet is indicated in:
- Anesthesia and/or infiltrative analgesia, local tissues; and structures, (concentric, eccentric, in depth, superficial and ring technique).
- Anesthesia and/or epidural analgesia. By single or continuous dose.
- Block of intercostal nerves.
- Intrapleural anesthesia and/or analgesia.
- Intravenous regional anesthesia (Bier´s block).
- Analgesia and/or infiltrative anesthesia intra and/or peri articular
- Regional or truncular nerve block, obstetric, urogenital, corrective and ocular surgery.
- Peripheral nerve block. Diagnostic perineural, truncular and multitruncular anesthesia.
Recommended for use in large and small animals of all breed, sex and ages.
Bupinex Vet must be administered with hypodermic needle and syringe, respecting all the appropriate asepsis and antisepsis regulation to maintain the sterility of the product and the structures to be anesthetized.
Bupinex Vet can be used following the same doses and volumes used for the use of Lidocaine Hydrochloride.
The greater the volume of anesthetic injected and the maximum concentration (0, 50%), the greater the desensitized area, and the longer the duration of its effect.
It is indicated as a general reference dose:
0, 25 mg/kg of weight, equivalent to 0,05 mL/kg of weight.
In cats it is suggested not to use doses higher than 5 mg/kg of weight. The indicative dose will depend on the requirement of the structure to be anesthetized and the type of maneuver to be performed.
Tissue and structure anesthesia for minor surgical maneuvers:
Bupinex Vet may be used in a 0, 25% dilution in water for Injection or Lidocaine 2%.
Anesthesia and blockages of large nerve trunks: It is recommended to use the original 0, 50% solution.
Epidural and subarachnoid anesthesia:
Epidural anesthesia is characterized by regional blockage caused by the anesthetic once injected into the epidural space.
The blockage occurs in the spinal nerves affecting the sympathetic, sensory and motor fibers. This technique is indicated to perform surgical procedures in the epigastric region, orthopedic surgery of the hip, perineum, posterior limbs, pelvis (rectum, vagina, bladder and urethra) soft tissue surgery in the posterior limbs, spinal analgesia, caesarean surgery and obstetric maneuvers.
It is suggested for this route, to use the original concentration of Bupivacaine at 0, 50%
Do not exceed an infusion rate greater than 0,5 mL every 20 seconds.
Dogs and Cats: 1 mL every 4, 5 kg of weight. This dose can be reduced by up to 30% in obese patients.
Swine: 1, 0 mL for every 10 kg of weight.
Horses: Post anesthesia apply 5 to 7 mL of Bupinex Vet 0, 50% (1 mL every 100 kg of weight approximately), to achieve subsequent anesthesia with station maintenance.
Exceeding these doses, the animal should be expected to lie down due to anterior block.
These doses should be reduced in elderly patients or where an anatomic reduction of the lumen of the medullary canal is anticipated. This precaution must be taken into account so as not to provoke an undesired decubitus of the animal, due to a previous blockage.
In horses, the latency time of the drug epidurally is 10 to 30 minutes. This time is longer than in cattle because the fatty tissue in the medullary canal of horses is longer. The duration of the analgesic effect normally lasts between 60 to 90 minutes.
- Post anesthesia: 8 to 10 mL total. Approximate duration of the analgesic effect: 2 hours.
- Previous anesthesia: When it is essential to recumbent the animal by this route, between 50 to 60 mL total of Bupinex Vet 0,50 % should be used. In these cases, effort will be made to keep the animal immobilized for 3 to 4 hours to avoid self-trauma
Collateral and secondary actions
It does not have at the doses and frequencies indicated.
There have been no hypersensitive reactions to the drug.
Histotoxic and neurotoxicity lesions have been described when the anesthetic is applied by the intraneural and no perineural route.
It should be borne in mind that, although very rarely, cases of patient refractory to the use of local anesthetic agents are described. This situation is observed more frequently with epidural administration.
Do not use in infected tissues (abscesses) or in recently traumatized regions, with the presence of pus, bruises and/or effusions.
It is not indicated for use as a topical or surface anesthetic on the mucosa.
Always carry out the “aspiration” maneuver, prior to the infiltration of tissues and/or structures with the medication, thus corroborating not to administer the product intravenously.
The intravenous route will be used exclusively to perform the intravenous regional anesthesia technique (Bier´s block).
Its iatrogenic administration intravenously may cause symptoms such as bradycardia, dysrhytmias, ventricular fibrillation and hypotension.
- Do not mix in the same bottle or syringe with any other compound other than those suggested to achieve a reduction of the original concentration.
- Do not eat. Keep out of the reach of children and domestic animals.
- Store the product below 30ºC, protected from light, in a dry and hygienic place.
- Verify that the products inviolability system and that its storage and conservation conditions prior to its use are adequate.
The suggested doses and warnings in all cases are for the consideration of the acting veterinarian.
Withdrawal period: Does not have.
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