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ISOFLURANO USP – VETERINARY USE
Ineltano Vet. Volatile liquid for use in inhalation anesthesia.
Isoflurane * 100.0 %
*1-chloro-2,2,2-trifluroethyl difluoromethyl ether
Indications of use:
INELTANO Vet, is a general anesthetic for inhalation use. It is probably the most clinically useful general anesthetic, which comes closest to the ideal in terms of biotransformation. It does not increase CNS irritability and does not induce muscle contracture or convulsive activity during anesthesia.
Its use is recommended in weakened patients and in those with liver or kidney disorders. It is an anesthetic of choice due to its safety, non-flammable characteristic, power and versatility in its control.
It provides a fast induction and recovery of the anesthetic plane with minimum side effects on the patient. This anesthetic is recommended for all types of high, medium and low complexity surgeries, because its actions as a hypnotic, analgesic and muscle relaxant are optimal.
Recommended for use in cats, dogs, ornamental birds, reptiles and horses.
Mode of Use:
Volatile anesthetic of specific use by inhalation.
Its administration may be performed after endotracheal intubation of the patient (with endotracheal tubes of appropriate measures), for which it will be necessary to abolish the laryngeal reflex through the use of an appropriate hypnotic agent (Thiopental, Propofol, Midazolam, Ketamine).
Induction and intubation may also be performed, administering INELTANO Vet directly, through a face mask or induction chamber, as appropriate.
Maintenance of anesthesia will be performed by vaporization of the anesthetic agent using a specific vaporizer and an inhalation anesthesia system or circuit that is adapted or corresponds to the species or patient to be treated (circular or non-rebreathing circuit). With the use of the non- rebreathing circuits, induction and recovery are faster. The use of semi-closed systems is recommended.
All dosages are indicative, since the actual dose will depend on the type of vaporizer to be used and the anesthetic plane to be reached. The dosage will be monitored according to the patient’s breathing frequency, heart rate and rhythm and blood pressure, important values that should always be parameterized with the sensitivity, muscle relaxation and control signs of the anesthetic plane (pupil reflex, palpebral, lingual and consciousness) intraoperatively in relation to the percentages of vaporized anesthetic.
Dogs and cats:
Induction: 2.0 – 5.0 %
Maintenance: 1.5 – 2.5 %
Induction: 3.0 – 5.0 %
Maintenance: 1.5 – 1.8 %
Identical protocol can be used in animals over 100 kg.
Induction: Can be placed in a plastic bag or an induction chamber. The chamber is filled with gas and sealed. Induction time can be 30 – 60 minutes, but can be reduced to 15 – 30 minutes if the animal is injected with 10 – 20 mg/kg of Ketamine (SC or IM), turtles should be sedated with 20 – 40 mg/kg of Ketamine IM. The anaesthetic level can be determined by the loss of reflexes. After induction, a mask, endotracheal tube or keeping the head inside the chamber can be used.
Maintenance: 3 – 5 %.
Ornamental birds: They can also be placed in an induction chamber or by using a face mask. They are anesthetized in about 15 – 30 seconds at 4 %.
The maintenance doses for all species, should always be the minimum possible with which it is achieved to maintain the required anesthetic level according to the characteristics of the surgical intervention to be performed.
If possible, it is recommended not to expose the animal to a new anesthesia until 20 days after the first one. This consideration is generally expressed by the conditions of surgical stress and not by problems of dosage with the agent.
EFFECTS ON ORGANS AND SYSTEMS:
Central Nervous System: It is capable of depressing all CNS functions. The induction of anesthesia is fast, from 3 to 5 minutes, with recovery being between 5 and 15 minutes when the vaporization of the agent is stopped. Recovery is rapid due to its low plasma solubility and the animal’s sensorium is clear and slightly depressed.
Cardio-respiratory system: As it produces myocardial depression, central venous pressure increases. The ISOFLURANO produces cardiopulmonary depression proportional to the anesthetic depth level. A hypotensive effect is described in relation to high concentrations of anesthetic, which will be reversed by decreasing or ending the administration of the agent. The cardio-inhibitory effect can be suppressed by the administration of atropine.
Respiratory depression as the anesthesia deepens, coupled with hypoventilation, leads to the development of acidosis, which is reversed with pure oxygen ventilation.
About the thermoregulatory function: it depresses the thermoregulatory mechanism of the hypothalamus. The environmental temperature should be controlled in order to prevent hypo- or hyperthermia.
Effects on the fetus: it quickly crosses the placenta, but does not produce any depression on the respiratory activity of the newborn.
CONTRAINDICATIONS AND PRECAUTIONS:
It is contraindicated in patients with a history of malignant hyperthermia. It should be used with caution (evaluate risk-benefit) in patients with severe liver failure, cardiac arrhythmias, myasthenia gravis.
The doses and warnings suggested in all cases are to be considered by the acting veterinary doctor.
Verify that the closure system of the product and its storage conditions prior to use are adequate.
Control the vital parameters of the animal permanently, including its body temperature, during the administration of the anesthetic.
Whenever this type of anesthetic agent or any other is used in patients with early or full-term pregnancy, the acting professional should evaluate the anesthetic score according to the particular case and determine together with the surgeon the risk-benefit position.
Hypotension may occur and is considered dose-dependent. It can be treated with the use of Dobutamine.
Although rarely, it can produce cardiac depression and dysrhythmias, which can be controlled with Lidocaine.
Not to be used in horses destined for human consumption.
SAFETY FOR THE USER:
May cause skin irritation. Avoid contact with eyes. May cause organic damage when oral exposure to high doses occurs.
Ensure adequate ventilation during use. Do not breathe vapors.
Keep out of reach of children.
First Aid: In case of severe acute exposure, remove operator from exposure area, consult physician immediately and show label. Wash any skin contact with plenty of soap and water. Eye contamination should be washed off with plenty of water for at least 10 minutes.
CONSERVATION: Keep between 15 and 25 ºC.
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