INERAN

Ineran

Trademark of Richmond Vet Pharma

Synthetic injectable Oxytocin 10 IU/mL

Veterinary Use

Ineran. Purified synthetic Oxytocin, for use in large and small animals. Ready to use injectable sterile solution.

Ineran is a highly purified Oxytocin, obtained by synthesis of the original active substance, extracted from the posterior lobe of the pituitary gland of domestic animals destined to slaughter.

Ineran is an aqueous injectable solution, which contains the equivalent of 10 USP units of Oxytocin with less than 0,2 units of vasopressor action per mL of solution. It has not antidiuretic activity.

Bioactivity

Ineran acts directly on the smooth musculature of the uterus in all species, producing rhythmic and synchronous contractions in it.

It is shown that in certain animal species, the cervix usually does not respond with contraction to the effects of oxytocin.

The degree of uterine activity induced by the effects of oxytocin, depends largely on the stage of reproductive cycle in which the animal is at the time of administration.

Estrogen and progesterone levels in the different stages of pregnancy, act as the main mechanism of control in the activity of oxytocin on the uterine musculature.

During the early stage of the pregnancy the uterus is relatively insensitive to the action of oxytocin increasing as the pregnancy reaches its end.

Ineran has an activity in close relation to the milk let down and it galactogogue effect. The mechanism by which the discharge of milk by the mammary gland occurs is still unknown, but it is assumed that oxytocin acts directly on certain elements of the smooth musculature in the mammary gland such us the myoepithelial cells surrounding the constituent alveoli of the gland. An effect proven for oxytocin is the ability of the drug to effectively promote milk let down.

Indications

Ineran is indicated in relation to its action on the uterine musculature in the following situations:

• Induction of  parturition.
• Accelerate normal parturition, or reverse a state of uterine inertia.
• Post partum evacuation of lochia and / or retained placenta.
• Uterine contraction and rehabilitation after a caesarean section and control of uterine hemorrhage.
• Stimulation of milk let down in appropriate physiological conditions.
• Optimize the involution of the uterus after giving birth to large fetus.

Administration

For obstetric use, the oxytocin may be administered intravenously or intramuscularly under appropriate aseptic and antiseptic conditions.

To achieve a faster effect on the stimulation of milk let down, the intravenous route is the most appropriate.

After intravenous administration, the drug acts on the uterine musculature immediately. Through the intramuscular route its effect is present between 3 to 5 minutes.

In dogs the duration of the effect of the drug, after been applied by IV/IM route is 13 to 20 minutes respectively.

Small amounts of the drug can cross the placental barrier and therefore to the fetal circulation. This erratic effect does not produce any depression on the fetus.

Indicative Dosage

The treatment should be continued following the indications in the dosage chart or until the desired effect is achieved, respecting the routes and frequencies expressed in the dosing table. It is suggested to start with the lowest dose of the range and if necessary repeat the treatment.

References: IV intravenously, IM intramuscular, SC subcutaneous.

Contraindications

Do not administer in cases of dystocia due to fetal presentation, until the position has been corrected.

Collateral and Secondary Actions

It does not have at the doses and frequencies indicated. There have been no hypersensitivity reactions to the drug.

Precautions

Oxytocin is a potent drug, which should be administered under prescription and medical control. For pre-parturition use, the total dilation of the cervix should be expected physiologically or by the administration of estrogens prior to oxytocin therapy.

Warnings

• Do not administer to animals in a state of hypocalcemia and/or severe hypoglycemia.
• Do not mix in the same syringe with any other compound.
• Do not eat. Keep out of the reach of children and domestic animals.
• Store below 30 ºC, protected from light, in a dry and hygienic place. The product may also be stored between 2 to 8 ºC (not in freezer).
• Verify that the product inviolability system and storage conditions prior to use are adequate.
• The doses and warnings suggested in all cases are of the consideration of the acting veterinarian. Withdrawal period: Does not own.

Overdose

The effect of overdosing will depend on the state of the uterus and the fetal position. Hypertonic or tetanus contractions may occur, causing abrupt labor, uterine rupture, damage or fetal death.

Water poisoning can manifest itself, if large doses of oxytocin are administered accompanied by the administration of free-flowing fluids.

UNDER ACHIEVED VETERINARY PRESCRIPTION ONLY

Ineran. Vials containing 50 mL and 100 mL of Injectable Sterile Solution of synthetic oxytocin 10 IU/mL.